Avoid fructose and turn the moment of having sweet into a sweet moment being with your child.

Diet intervention for children with autism spectrum disorder (ASD) has been ongoing research, with theories including a link to impaired gut function in children with ASD and the connection between the gut and the brain. Some dietary interventions are designed to help address specific symptoms or problems associated with ASD, and these interventions are not direct treatments. Still, they are often used as complementary therapies to manage the severity or particular aspects of the condition. 

One primary dietary intervention that Dr. Tomato is particularly interested in is the elimination of fructose from the meal.

The primary cause of autism is a viral infection, and the bacterial infection of the gut causes the rapid progression of autism.  A fructose-free diet is essential to stop the rapid growth of gut bacteria. Many studies and papers support the link between the autism spectrum and increased fructose intake. 

Intergenerational Metabolic Syndrome and Neuronal Network Hyperexcitability in Autism /Aileen Rivell1 and Mark P. Mattson 2019 PMCID: PMC6779523 highlighted that ” The rapid increase in the prevalence of autism spectrum disorders (ASD) during the past 40 years is associated with excessive dietary energy intake, particularly fructose, and a concomitant increase in metabolic syndrome (obesity, insulin resistance and hyperlipidemia)

Numerous research have also been done and published explaining the link between fructose and the autism spectrum.  (See. Ref. below) Dr. Tomato’s clinical studies found that restricting sugar intake alone improved several asocial behaviors and symptoms in children with autism.

What is fructose? 

Fructose is a sugar found naturally in fruits, fruit juices, some vegetables, and honey. Fructose is also a primary ingredient in table sugar (sucrose), and high fructose corn syrup is used to sweeten many processed foods and beverages. It is a common sweetening additive in all fruits, commercially prepared foods, and ready-to-eat foods, so observe the label

It’s never a good idea to give your child a sweet because you feel sorry for them. If you think about the impact that a brief moment of pleasure from a sugary treat could have in the distant future, you’d be more likely to put it in a drawer and give it up for a while, like an unknown food or taste. You’d probably never give your child anything with fructose if you were convinced of its consequences.  Avoid fructose and turn the moment of eating sweet into a sweet moment with your child.


High Fructose Corn Syrup, Mercury, and Autism – Is there a Link?/ Heather A. Opalinski Journal of the American Academy of Special Education Professionals (JAASEP)

Association of sugar-sweetened beverages with executive function in autistic children, Frontiers in Nutrition 2022

Neurobehavioral effects of long-term maternal fructose intake in rat offspring/ Erbas, MA Erdogan, A Khalilnezhad / International Journal of Developmental Neuroscience

Maternal fructose consumption disrupts brain development of offspring in a murine model of autism spectrum disorder AF Saad, W Alshehri, J Lei… – American journal of …, 2016 –

High Fructose Corn Syrup, Mercury, and Autism–Is There a Link?.

HA Opalinski – Journal of the American Academy of Special Education …, 2012 – ERIC

Case study: The effects of excess fructose in a patient with autism spectrum disorder infections

Intergenerational metabolic syndrome and neuronal network hyperexcitability in autism

A Rivell, MP Mattson – Trends in neurosciences, 2019

A macroepigenetic approach to identify factors responsible for the autism epidemic in the United States R Dufault, WJ Lukiw, R Crider… – Clinical …, 2012 –

Current nutritional approaches in managing autism spectrum disorder: A review

H Cekici, N Sanlier – Nutritional neuroscience, 2019 – Taylor & Francis

Osmotic avoidance in Caenorhabditis elegans: synaptic function of two genes, orthologues of human NRXN1 and NLGN1, as candidates for autism F Calahorro, E Alejandre, M Ruiz-Rubio – JoVE (Journal of Visualized …, 2009

Ming X, Stein TP, Barnes V, Rhodes N, Guo L. Metabolic perturbance in autism spectrum disorders: a metabolomics study. J Proteome Res. 2008

Herndon AC, DiGuiseppi C, Johnson SL, Leiferman J, Reynolds A. Does nutritional intake differ between children with autism spectrum disorders and children with typical development? J Autism Dev Disord. 2009.

Emond P, Mavel S, Aidoud N, Nadal-Desbarats L, Montigny F, Bonnet-Brilhault F, et al. GC-MS-based urine metabolic profiling of autism spectrum disorders. Anal Bioanal Chem. 2013 Jun

Wang L, Angley MT, Gerber JP, Sorich MJ. A review of candidate urinary biomarkers for autism spectrum disorder. Proteomics-Clin Appl. 2013 Dec;7

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